Advantages of ultrasonic crystallization

Ultrasonic wave can effectively improve the post process of crystal products, and one of the main purposes of the ultrasonic wave in the crystallization process is to solve the bottleneck problem in the post process.

The main effect of ultrasonic wave in the crystallization process:

1 to adjust the crystal size, particle size is smaller than the traditional method

2 to improve particle size distribution, distribution is more uniform

3 shorten the crystallization time, the nucleation time is shorter.

4 ultrasound can accelerate the growth rate of the crystal to prevent the occurrence of coalescence, while changing the structure of the crystal, so as to improve the performance of crystalline products.

The size and shape control of ultrasonic crystals can produce the following advantages:

1 to speed up the filtration rate, particle size distribution of the small size of the crystal filter rate is usually faster, but only a fraction of the traditional crystal.

2 ultrasound can improve the quality of products to speed up the washing and drying rate, filtration cycle and then reduce the degree of contamination of crystal products.

3 a large number of crystal grinding process may lead to pollutants in the product, and it may pollute the environment, the crystal size of the control by ultrasonic, can be in the production of

Eliminate this step.

4 ultrasound can effectively reduce the difficulty of the product filling process. Because the flow of the product that passes through the ultrasonic waves is usually a big increase. At the same time

Heap density also has a considerable increase, or even more than two times.

5 ultrasound can be used in a sterile environment, usually sterile solution is very clean, the lack of internal suspension, the solution is usually difficult to nuclear.

Destruction of sterile conditions, ultrasonic crystallization will be well resolved.

Ultrasonic wave can be used to improve the size distribution of crystal products, shorten the crystallization time, and have a certain effect on the size of the crystal. So it is in the process of crystallization,

Especially for the product size and size distribution has a higher requirements of the occasion. Such as pharmaceutical products will play a more important role in the crystallization process, the ultrasonic can promote the nucleation, improve

The crystal distribution of the crystal product is better than that of the crystal, so that it can avoid the burst nucleation caused by the crystallization under the condition of high degree of saturation. Ultrasound can significantly shorten the crystallization of

Induce time, reduce the width of the metastable zone, prevent the aggregation of the crystals, and change the crystal habit. In the post crystallization process of the crystal, the fine crystal is produced by the action of ultrasonic wave,

Avoid grinding in the later stage.

Ultrasound can not only make the solid solute of the over saturated solution to produce rapid and gentle precipitation, but also can strengthen the crystal growth. Solution crystallization in organic soluble substances and inorganic salts

Separation and purification has a very important role. It can not only separate the solute from the solution in the solid state, but also because of the different crystal lattice.

It can be used to purify the product. Compared with other methods, the degree of saturation is lower and the growth rate is faster. The crystal nuclei are more uniform,

Complete and smooth, crystal core and crystal size distribution of smaller size, lower coefficient of variation. But the micro jet generated by the collapse of the ultrasonic cavitation bubble has a concave function on the surface of the crystal.

Over the meeting broke the crystal, the destruction of growth.